Betting prediction: Empoli haven't had much to shout about this season, but they could snatch a narrow win in the cup.
The Serie A sides enter the competition and strugglers Empoli could have something to cheer in Tuscany.
Cesena's away form in Serie B has been exceptionally poor and there's little evidence to suggest a shock here.
Bet365 make Empoli 17/20 favourites with Cesena priced at 29/10. They priced the draw at 23/10.
Empoli were easily swept aside on Saturday evening at home to AC Milan, but they managed to find the back of the net, which is something they've found great difficulty doing so far.
It was their first goal at home since the 12th of September and just their 7th of the season. They've had issues in front of goals all season, but strangely hit four away at Pescara at the start of the month.
No Empoli player can boast more than 2 goals so far this season with Massimo Maccarone and Saturday's scorer Riccardo Saponara sharing just four between them so far.
All of those factors point towards a possible shock here, but Cesena's away form in Serie B is nothing to write home about. They are yet to win on their travels, have picked up just three points and scored just five times in eight away games.
They've won just twice in 21 away matches and opposition in Serie B is significantly weaker than Empoli, even with their lack of cutting edge.
They picked up a morale boosting win at the weekend, a convincing 3-0 victory over Avellino, who sacked their manager as a result of the defeat.
That victory moved them out of the relegation places, but it's their home form which is keeping them afloat.
Back Empoli at 17/20 with Bet365
Back correct scores 1-0 at 5/1 and 2-0 at 7/1 with Bet365
Try Under 2.5 Goals in this one at 3/5