Betting tip: The leader's fatigue could catch up with them on Wednesday night.
Nice had lots of possession on Sunday, but lacked a killer instinct and this is a tough away trip for them.
Nice weren'table to kill off Bastia on Sunday and looked tired in the closing stages of the game.
Bet365 bookmaker make Guingamp 29/20 for this game with Nice priced at 2/1 for victory
Nice still lead the way in Ligue 1, but that lead has been cut to just a single point. Victories for Monaco and PSG this weekend leave both sides breathing down the necks of Les Rouges et Noir, who must surely be feeling the pressure.
Lucien Favre's side were beaten in the Europa League by an upwardly mobile before being held to a 1-1 draw in Ligue 1 by Bastia. The hosts had the lead in that match, but looked tired in the second half and despite having around 30 minutes to win the game, they ran out of ideas.
They remain solid and aren't going to cave in at any point, but perhaps their lack of potency in the final third will see them drop off the pace.
They've made a terrific start to the season and another season in Europe surely beckons, but even L'Equipe suggested on Tuesday that they will plateau leaving Unai Emery and Leonardo Jardim to fight for the title.
Guingamp are one of the better sides in Ligue 1 this season and have proved consistent. They currently sit 5th in the table and are unbeaten in six. They are unbeaten at Stade Du Roudourou where they have conceded just three goals all season.
They keep things tight here and they will not give Nice space to create. Although they've not welcomed any of Ligue 1's powerhouses here yet, they have beaten Marseille, Angers and Lille whilst holding Bordeaux and Montpellier to 1-1 draws.
Antoine Koumbare rested a few of his key players at the weekend as his side drew 1-1 with Caen ahead of this tie and they will be fresh and raring to go.
Back Guingamp on the Draw No Bet market at 8/11 with Bet365 bookmaker.
At the same priced of 8/11, it's definitely worth backing Under 2.5 Goals with Bet365.
Nill De Pauw might not start this one, but has a habit of coming off the bench and scoring late. He's netted a few times at crucial points this season and is 9/2 anytime with Bet365