Betting tip: With the game wrapped up after the first leg, expect Zidane to give the fringe players a chance to shine.
They've pretty much booked their place in the Round of 16 and Zidane will use it as a warm up for El Clasico at the weekend.
It's hard to see Leonesa threatening Real Madrid at the Bernabeu, but the 1st leg was a very entertaining affair.
Bet365 make Real Madrid 1/16 with Leonesa 28/1 for a victory
There are plenty of youngster waiting in the wings at Real Madrid and many of them will fancy their chances of getting a game here.
A fairly strong team was sent out in the 1st leg with the likes of Isco, Danilo, Morata and Toni Kroos all featuring.
Once again, it appears the likes of Danilo will feature and he is likely to be joined by Casemiro, Nacho, James Rondriguez and Asensio for this.
Zidane will be looking towards El Clasico and is already without Gareth Bale this weekend. Although, he is likely to see this as a good chance to warm up for the clash, he cannot afford to lose any players to injury.
Cristiano Ronaldo has joined to the team to train ahead of this match, but is very unlikely to be offered a place in the squad.
The likes of Marco Asensio and Casemiro will see this as a chance to impress the boss and feature more prominently in the second half of the season.
Alvaro Morata scored a brace in the first leg and is likely to feature in some capacity here.
Leonesa sit top of Segunda B Group 1 and have been enjoying a terrific season so far. They will travel South for this fixture hoping to take advantage of a much-changed Madrid outfit.
Back Real Madrid and Over 4.5 Goals here at Evens with Bet365. Real Madrid will score a few and Leonesa might fancy their chances of getting on the scoresheet again.
Take the short price of 4/7 for Over 1.5 first half goals in this.
Back Over 2.5 second half goals at Evens with Bet365 and Over 3.5 Real Madrid team goals at 4/5.