There is precious little evidence to suggest Palermo will find this easy.
Serie A strugglers take on play-off hunting Serie B side. Surely a recipe for a shock?
Palermo haven't had much to shout about so far this season and they won't want to add another black mark to their name by losing to Spezia.
Bet365 make Palermo 23/20 for this match with Spezia priced at 5/2
Palermo will see this game as a chance to end a long losing run in Serie A.
The 21st of September was the last time they collect three points and their long suffering fans must be finding it difficult to cling onto positives.
They were better on Sunday morning as they hosted Lazio here. The in-form side arrived from Rome and left with all three points, but the hosts didn't make it easy for them.
In the process of defeat, the Sicilian outfit made it a club record seventh consecutive defeat.
A tap in was the difference in the end, just one moment, a lapse in concentration and it was game over.
Coach Roberto Di Zerbi has come under scrutiny in recent weeks and the pressure is mounting. Considering the trigger finger possessed by the clubs chairman, it's remarkable that Di Zerbi is still in the hotseat, but he will be looking to buy himself some time with victory in the cup.
Normally, a home draw would be an advantage, but Stadio Barbera hasn't been kind to them and they haven't picked up a single point here so far. They did ease past Bari in the early rounds of the competition, but needed extra time to do so.
Spezia should be confident of an upset here. The Serie B side drew 1-1 in their derby match with Entella at the weekend and played the last 5 minutes with ten men.
Their away form has been mixed this season, but they have beaten Udinese already in this competition, so won't be shy in attacking the beleaguered hosts.
They've drawn 5 of their 8 away league games this season, losing just twice. They've only conceded 5 goals on the road and no side has put more than a single strike past them. They will be up for this.
Take a chance on Spezia to Qualify here. They're 6/5 with Bet365 and are much better value shot than the short price on the Serie A side.
Take 3/4 for Under 2.5 Goals here. Neither side are prolific, but Spezia are decent at the back.
One goal could be enough here, take 9/4 for Under 2 Goals in this game with Bet365