Both teams will prioritise the match on Sunday, but this could be an open and entertaining game.
Bet365 make Sevilla 13/8 for this with Real Madrid priced at 6/4
Real Madrid bring the comfortable 3-0 cushion into this second leg and will be confident about their progression in the competition.
Sevilla had chances late on last week, but couldn't cut the deficit and it's looking like a difficult task for the hosts at Estadio Ramon Sanchez Pizjuan.
These sides face each other once more on Sunday night here and both managers have talked up the importance of that game. With Barcelona slipping up on Sunday, it gives both sides the chance to boost their title credentials this weekend. Sevilla are looking to cut the gap on Los Blancos at the top of the table and a victory would bring them within a point of the leaders.
Real Madrid are hoping to stretch their lead at the summit and could potentially go 6 or 7 points at the top of La Liga.
Zidane will certainly place his trust in his fringe players for this game although goalscorer James Rodriguez is an injury doubt for this fixture. Cristiano Ronaldo will once again be rested alongside Luka Modric who has played both matches in 2017. Isco, Pepe and Gareth Bale are the other players to miss out.
Stefan Jovetic has signed for Sevilla this week, but is unlikely to feature in either of the two encounters with Real Madrid. Clement Lenglet is another new arrival who is likelier feature in this one.
Jorge Sampaoli has said his side will still try and salvage something from this tie but his priorities lie with Sunday's league match. He's compared the weekend showdown to a final and is looking forward to the challenge.
After last week's humbling, they come into this tie full of confidence following a 4-0 victory in San Sebastian against Real Sociedad.
They have a good record against Real Madrid here having won four of the last five hostings of this fixture.
Sevilla recent form (League) - W W W L W
Real Madrid recent form (League) - W W D W W
Sevilla won 3-2 here in November 2015
Take 8/11 for Over 2.5 Goals and Both Teams to Score? Yes with Bet365
Also, take a chance on Over 3.5 Goals at 6/5
5/6 is available for a goal after 76:59 minutes
Back Wissam Ben Yedder to score for Sevilla at 7/5 anytime with Bet365